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Bisoren 10mg Tablet 1 Strip
Bisoren is used to treat:
✔ Hypertension (High Blood Pressure)
✔ Angina (Chest Pain)
✔ Moderate to Severe Heart Failure
🚫 Not recommended for emergency treatment of hypertensive crises.
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✅ Description:
Bisoren (Bisoprolol) is a highly selective β1-blocker used for hypertension, angina, and heart failure. It offers once-daily dosing with minimal fluctuations in drug levels.
Bisoprolol is the most selective β1-blocker available. It selectively blocks β1-adrenergic receptors in the heart and vascular smooth muscle, reducing:
- Heart rate
- Cardiac output
- Blood pressure
✔ Unlike non-selective beta-blockers, Bisoprolol does not negatively affect lipid metabolism (cholesterol levels).
✔ It has a long half-life (10-12 hours), allowing for once-daily dosing with minimal fluctuations in blood levels.
Pharmacokinetics
✔ Absorption: Rapid absorption (>90%) from the GI tract, bioavailability 88%.
✔ Metabolism: Mainly metabolized in the liver (CYP3A4 pathway), but does not require conjugation.
✔ Elimination: Balanced between renal excretion (50%) and hepatic metabolism (50%).
✔ Half-life: 10–12 hours, supporting once-daily dosing.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration of Bisoren 10
✔ Adults (Hypertension & Angina):
- Start with 5 mg once daily (alone or with a diuretic).
- If needed, increase to 10 mg once daily, then to 20 mg once daily.
- Maximum effective dose: 20 mg/day.
- Titrate dose every 2 weeks if needed.
✔ Patients with Renal or Hepatic Impairment:
- Start with 5 mg once daily.
- Use caution with dose increases (risk of drug accumulation).
- Not removed by dialysis—no need for replacement dosing.
✔ Elderly Patients:
- Usually no dose adjustment needed unless severe renal or hepatic dysfunction is present.
🚫 Children:
- Safety and effectiveness not established—not recommended.
✔️ Side Effects of Bisoren 10
✔ Common Side Effects:
- Fatigue & Dizziness
- Headache
- Digestive Issues – Nausea, vomiting, diarrhea, constipation, abdominal pain
- Cold or numb hands and feet
- Muscle weakness or cramps
✔ Less Common but Serious Side Effects:
- Slow heart rate (bradycardia)
- Breathing difficulties (bronchospasm) in asthma or COPD patients
- Severe hypotension (low blood pressure)
✔️ Avoid combining Bisoren with:
- Other β-blockers – Risk of excessive bradycardia or hypotension.
- Catecholamine-depleting drugs (e.g., reserpine, guanethidine) – May lead to excessive suppression of sympathetic activity.
- Centrally Acting Antihypertensives (e.g., Clonidine) – Can cause rebound hypertension when discontinued. If used together:
- Taper off β-blocker first, then stop clonidine a few days later.
- Antiarrhythmic Agents (e.g., Verapamil, Diltiazem, Disopyramide) – Can cause bradycardia, conduction issues, severe hypotension, or heart failure.
- Calcium Channel Blockers (e.g., Amlodipine, Diltiazem, Verapamil) – Risk of excessive heart rate slowing and low blood pressure.
✔️ Do NOT use Bisoren if you have:
- Cardiogenic shock
- Overt heart failure
- Severe A-V block (2nd or 3rd degree)
- Severe sinus bradycardia
- Right ventricular failure due to pulmonary hypertension
✔️ Benefits: Bisoren 10
✔ Effective in reducing heart rate and blood pressure
✔ Less effect on lipid metabolism compared to other beta-blockers
✔ Requires careful dose adjustments in kidney/liver disease
✔ Avoid abrupt discontinuation—always taper off under medical supervision
✔️ Use in Pregnancy & Lactation
⚠ Pregnancy:
- Bisoprolol was not teratogenic in animal studies, but can be toxic at high doses.
- Limited human data – should only be used if benefits outweigh risks.
⚠ Lactation:
- Small amounts of Bisoprolol are excreted in animal milk—unknown for humans.
- If essential for the mother, breastfeeding should be stopped.
✔️ Use Bisoren with caution in:
✔ Impaired Kidney or Liver Function – May require dose adjustments.
✔ History of Severe Allergic Reactions – May have reduced response to epinephrine during anaphylaxis.
✔ Asthma or COPD – Risk of bronchospasm; use with caution.
✔ Diabetes – Can mask symptoms of low blood sugar (hypoglycemia).
✔ Thyroid Disorders – Can mask symptoms of hyperthyroidism.
✔ Heart Block or Low Heart Rate – Risk of worsening bradycardia.
✔️ Storage:
✔ Store in a cool, dry place (below 25°C).
✔ Keep away from heat, light, and moisture.
✔ Keep out of reach of children.
